I started 100 mg of oral progesterone a little over a week ago, and I haven’t had a good nights sleep in at least 5 days. I wake up between 2 and 4 in the morning, usually within a half hour of 3. Sometimes from a nightmare, which I never used to have until I realized I was trans, sometimes I’m just awake. Last night I didn’t sleep at all so far as I can tell. I see most people saying it does the oppositw for them, just knocks them right out in underan hour, but I definitely don’t get that. I really don’t want the cause of my inability to sleep to be the prog because I’ve already noticed my boobs feel bigger, but has anyone else had this experience?


It depends on the dose and route of administration as to why it took 3 weeks for you to notice changes from estradiol. I noticed changes within hours to days - particularly after 3 days my mood pretty radically changes as my body stopped producing testosterone. (But I injected a significant enough dose of estradiol valerate, so the estrogen was peaking at day 3 instead of like day 7 - 8 with estradiol enanthate injections.)
I find prog definitely helps libido, but … I don’t know whether taking it orally will help with that or not (since it doesn’t raise blood levels). My experience with taking it orally is that it just doesn’t work, I think I felt a different kind of drowsy that didn’t help me stay asleep like when I take it rectally.