I’m interested in that feeling of relief some of us get after taking our estradiol dose. I experience it as intense relief that washes over me and bathes me in joy. My color perception dramatically improves at the same time, it’s a very sudden shift.
I seem to only experience it when my blood levels are too low and the new dose enters the blood. With Divigel it’s after 30 minutes have passed, in my case, but only if me levels are low.
Some questions I have:
- If I don’t feel the relief, am I overdosed?
- If I do feel the relief, am I underdosed?
- Why do I and some feel the relief, while others have never felt it?
I don’t expect anyone to know the definitive answers, but maybe you can share your experience? I’m really interested in learning what this is all about.


I had that as well, and a tiny bit of a feel like a hand clasped around your arm (that’s where I do the dose).
Switching up arms a few times in the first week or two stopped that. Now I usually just do it on the same arm and feel none of that clasp.