I’m interested in that feeling of relief some of us get after taking our estradiol dose. I experience it as intense relief that washes over me and bathes me in joy. My color perception dramatically improves at the same time, it’s a very sudden shift.
I seem to only experience it when my blood levels are too low and the new dose enters the blood. With Divigel it’s after 30 minutes have passed, in my case, but only if me levels are low.
Some questions I have:
- If I don’t feel the relief, am I overdosed?
- If I do feel the relief, am I underdosed?
- Why do I and some feel the relief, while others have never felt it?
I don’t expect anyone to know the definitive answers, but maybe you can share your experience? I’m really interested in learning what this is all about.


As others have mentioned it’s different for everyone!
In addition to all of us responding differently we also take HRT differently. I take enanthate injections every week and so at the end of the week I don’t feel much of a low because my levels are very stable. Would I feel a relief if I took HRT orally or transdermally and therefore had more swingy levels? Maybe. Maybe not. I certainly remember noticing changes more easily back when I did gel, but it was also early on in my transition and so perhaps things have changed now.